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АНАЛИЗ ИЗУЧЕННОСТИ, ПОЛОЖИТЕЛЬНЫЙ ОПЫТ И РЕКОМЕНДАЦИИ ПО ДИАГНОСТИКЕ И МЕРАМ БОРЬБЫ С ЧУМОЙ МЕЛКИХ ЖВАЧНЫХ

 

Журнал «НАУЧНАЯ ЖИЗНЬ»  [СКАЧАТЬ СТАТЬЮ В PDF]
т. 14, вып. 5, май 2019 

Рубрика: ВЕТЕРИНАРНАЯ МИКРОБИОЛОГИЯ, ВИРУСОЛОГИЯ И ИММУНОЛОГИЯ
Страницы:  706–713
DOI: 10.26088/INOB.2019.93.31130
   
Авторы: 

Падило Лариса Павловна, аспирант кафедры «Болезни животных и ветеринарно-санитарная экспертиза», ФГБОУ ВО «Саратовский государственный аграрный университет им. Н. И. Вавилова»: Россия, 410012, г. Саратов, Театральная пл., 1.

Тел.: (845-2) 23-32-92

Е-mail: medpavlov@gmail.com

   
Реферат:  В статье описаны общие сведения о возбудителе чумы мелких жвачных животных, описаны клинические признаки, принципы диагностики, дифференциальной диагностики, а также сведения об иммунитете при ЧМЖЖ и профилактике. Чума мелких жвачных является высококонтагиозной, трансграничной, эмерджентной болезнью. Занесенный вирус способен заразить до 100% поголовья. Болезнь протекает как правило сверхостро, остро и иногда подостро, при этом от 30 до 70% больных животных погибают. Передача вируса может происходить аэрогенным и алиментарным путем, при прямом контакте овец и коз с больными животными. Мелкие жвачные животные поражаются в первую очередь ЧМЖ и блютангом. Занесенный вирус способен заразить до 100% поголовья. Чума мелких жвачных наносит колоссальный экономический ущерб козоводству и овцеводству. Смертность в первичных очагах может достигать 100%, а на стационарно неблагополучных территориях – до 50,0%. Болезнь классифицирована как особо опасная инфекционная болезнь. Возбудитель ЧМЖЖ – РНК-содержащий вирус семейства парамиксовирусов (Рaramyxoviridae), рода морбиливирус (Morbillivirus). Вирус, имеет слегка овальную или шарообразную формы, размеры от 150–170 до 200–400 нм. Вирус, по морфологии, антигенному составу и иммунобиологическим свойствам близок к вирусу чумы крупного рогатого скота. Выделение вируса в культуре клеток и идентификация его в РН, обнаружение вирусного АГ в органах и тканях от павших и вынужденно убитых животных в РСК, РДП, ВИЭОФ, РТНГА, РИГА, РИФ, ИФА; обнаружение специфических АТ у переболевших животных в РСК, РН, РДП, РТГА, ИФА. У переболевших животных вырабатывается пожизненная устойчивость к вирулентному вирусу.
   
Ключевые слова: чума мелких жвачных, диагностика, профилактика и меры борьбы.
   

Список литературы:

1. Baron M., Diallo A., Lancelot R., Libeau G. Peste des petits ruminants virus. Adv. Virus Res. – 2016. 95. – Р. 1–42.

2. Bouchemla Fayssal, Olga Mikhailovna Popova and Valerey Alexandrovich Agoltsov. Analysis of spatial dynamic of epizootic process of bluetongue and its risk factors. Veterinary World, 10 (10) : 1173–1183.

3. Damian Tagoa, Baba Sall, Renaud Lancelot, Jennifer Pradel. Application to peste des petits ruminants (PPR) vaccination in Senegal. Veterinary Microbiology.Volume 206, July 2017. – P. 91–101.

4. Dhar P. et al. “Recent epidemiology of peste des petits ruminants virus (PPRV)”. Veterinary Microbiology. – 2002. 88 : 153–159.

5. DialloA. et al. “The threat of peste des petits ruminants: progress in vaccine development for disease control.” Vaccine. – 2007. 25 : 5591–5597.

6. Evaluation of variability in antibody response induced by vaccination against Peste des petits ruminants (PPR) in Malpura and Avikalin sheep. G. R. Gowane Najif Akram L. L. L. PrinceVed Prakash C. Paswan R. C. Sharma Arun Kumar. Small Ruminant Research.Volume 144, November 2016. – P. 104–108.

7. FAO– Organisation des Nations Unies pour lʼalimentation et lʼagriculture [Электронный ресурс]. – Режим доступа: http://www.fao.org.

8. Furley C. W., Taylor W. P., Obi T. U. An outbreak of peste des petits ruminants in a zoological collection. Vet Rec 1987; 121 (19): 443–7.

9. Gargadennec L. & LalanneA. (1942). La peste des petits ruminants. Bull. Serv. Zoo. A. O. F., 5, 15–21.

10. Gibbs E. P. J., Taylor W. P., Lawman M. J. P. & Bryant J. Classification of peste des petits ruminants virus as the fourth member of the genus Morbillivirus. – 1979. Intervirology, II. –Р. 268–274.

11. JeffreyC. MarinerJ, James Gachanja, Sheltone H. Tindih, Philip Toye. Athermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia. Vaccine 35. – 2017. – Р. 3773–3779.

12. M protein is sufficient for assembly and release of Peste des petits ruminants virus-like particles. Qiuxia Wanga et al. Microbial Pathogenesis. Volume 107, June 2017. – P. 81–87.

13. Abha Khandelwal Gourapura. J. Renukaradhya Malleshappa Rajasekhar G. Lakshmi Sitaa Melkote S. Shaila. Immune responses to hemagglutininneuraminidase protein of peste des petits ruminants virus expressed in transgenic peanut plants in sheep. Veterinary Immunology and Immunopathology. – Volume 140. – Issues 3–4, 15 April 2011. – P. 291–296.

14. Ahmad M. Al-Majalia, Nazmi O. Hussainb, Nadim M. Amarinc, Aggrey A. Majok. Seroprevalence of, and risk factors for, peste des petits ruminants in sheep and goats in Northern Jordan. Preventive Veterinary Medicine. – Volume 85. – Issues 1–2, 15 June 2008. – P. 1–8.

15. Ana Carina Silva, Marth Yami Geneviève, Libeau Manuel, J. T. Carrondoae, Paula M. Alves. Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia. Vaccine. – Volume 32. – Issue 24, 19 May 2014. – P. 2878–2881.

16. Assessment of the antibody response to Peste des petits ruminants (PPR) disease vaccination in a flock of Sirohi goat kids. G. R. Gowane Najif Akram S. S. Misra Ved Prakash Arun Kumar. Small Ruminant Research. – Volume 138, May 2016. – P. 20–24.

17. Balogun F. A. et al. Field evaluation and confirmation of acute peste des petits ruminant outbreak in a flock of West African dwarf goats in Ibadan, Nigeria. Int J of Vet Sci. Med. – 2017. [Электронный ресурс]. – Режим доступа: https://doi.org/10.1016/j.ijvsm.2017.08.004.

18. Banyard A. C., Parida S., Batten C., Oura C., Kwiatek O., Libeau G. Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control. J Gen Virol. – 2010; 91: 2885–97.

19. Bao J., Wang Q., Li L., Liu C., Zhang Z., Li J., Wang S., Wu X., Wang Z. Evolutionary dynamics of recent peste des petits ruminants virus epidemic in China during 2013–2014. VirologyVolume 510, October 2017. P. 156–164.

   
English version:

ANALYSIS OF PREVIOUS STUDY, POSITIVE EXPERIENCE AND RECOMMENDATIONS FOR DIAGNOSIS AND MEASURES TO COMBAT SMALL RUMINANT PLAGUE

Padilo Larisa Pavlovna, postgraduate student, Saratov State Vavilov Agrarian University, Saratov, Russia.

Keywords: small ruminant plague (peste des petits ruminants - PPR), diagnosis, prevention and control measures.

Abstract. The article gives general information about the causative agent of the plague of smallruminants, and describesthe clinicalsigns, the principles of diagnosis, differential diagnosis, as well as information about the PPR immunity and prophylaxis. Small ruminants plague is a highly contagious, transboundary and emergent disease. The introduced virus is capable of infecting up to 100% of the animal population. The disease usually proceeds as over-acute, acute and sometimes sub-acute, while from 30 to 70% of sick animals die. Transmission of the virus can occur through an aerogenic and alimentary route, with direct contact ofsheep and goats with sick animals. Small ruminants are affected primarily by the PPR and the Bluetongue. The introduced virusis capable of infecting up to 100% of the population. Smallruminant plague causes enormous economic damage to goat and sheep breeding. Mortality in primary foci can reach 100%, and in permanently deprived areas – up to 50%. The disease is classified as a particularly dangerous infectious disease. The causative agent of the PPR is an RNA-containing virus of the  paramyxovirus family (Paramyxoviridae), a genus of morbilivirus(Morbillivirus). The virus has a slightly oval or spherical shape, ranging in size from 150–170 to 200–400 nm. In terms of morphology, antigenic composition and immunobiological properties, the virus is similar to the cattle plague virus. The animals that have been ill develop life-long resistance to the virulent virus.

REFERENCES

1. Baron M., Diallo A., Lancelot R., Libeau G. Peste des petits ruminants virus. Adv. Virus Res. – 2016. 95. – Р. 1–42.

2. Bouchemla Fayssal, Olga Mikhailovna Popova and Valerey Alexandrovich Agoltsov. Analysis of spatial dynamic of epizootic process of bluetongue and its risk factors. Veterinary World, 10 (10) : 1173–1183.

3. Damian Tagoa, Baba Sall, Renaud Lancelot, Jennifer Pradel. Application to peste des petits ruminants (PPR) vaccination in Senegal. Veterinary Microbiology.Volume 206, July 2017. – P. 91–101.

4. Dhar P. et al. “Recent epidemiology of peste des petits ruminants virus (PPRV)”. Veterinary Microbiology. – 2002. 88 : 153–159.

5. Diallo A. et al. “The threat of peste des petits ruminants: progress in vaccine development for disease control.” Vaccine. – 2007. 25 : 5591–5597.

6. Evaluation of variability in antibody response induced by vaccination against Peste des petits ruminants (PPR) in Malpura and Avikalin sheep. G. R. Gowane Najif Akram L. L. L. PrinceVed Prakash C. Paswan R. C. Sharma Arun Kumar. Small Ruminant Research.Volume 144, November 2016. – P. 104–108.

7. FAO – Food and Agriculture Organization of the United Nations [Electronic resource] – Access Mode: http://www.fao.org.

8. Furley C. W., Taylor W. P., Obi T. U. An outbreak of peste des petits ruminants in a zoological collection. Vet Rec 1987; 121 (19): 443–7.

9. Gargadennec L. & Lalanne A. (1942). The plague of small ruminants. Bull. Serv. Zoo. A. O. F., 5, 15–21.

10. Gibbs E. P. J., Taylor W. P., Lawman M. J. P. & Bryant J. Classification of peste des petits ruminants virus as the fourth member of the genus Morbillivirus. – 1979. Intervirology, II. –Р. 268–274.

11. Jeffrey C. Mariner J, James Gachanja, Sheltone H. Tindih, Philip Toye. A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia. Vaccine 35. – 2017. – Р. 3773–3779.

12. M protein is sufficient for assembly and release of Peste des petits ruminants viruslike particles. Qiuxia Wanga et al. Microbial Pathogenesis.Volume 107, June 2017. – P. 81–87.

13. Abha Khandelwal Gourapura. J. Renukaradhya Malleshappa Rajasekhar G. Lakshmi Sitaa Melkote S. Shaila. Immune responses to hemagglutinin-neuraminidase protein of peste des petits ruminants virus expressed in transgenic peanut plants in sheep. Veterinary Immunology and Immunopathology. – Volume 140. – Issues 3–4, 15 April 2011. – P. 291–296.

14. Ahmad M. Al-Majalia, Nazmi O. Hussainb, Nadim M. Amarinc, Aggrey A. Majok. Seroprevalence of, and risk factors for, peste des petits ruminants in sheep and goats in Northern Jordan. Preventive Veterinary Medicine. – Volume 85. – Issues 1–2, 15 June 2008. – P. 1–8.

15. Ana Carina Silva, Marth Yami Geneviève, Libeau Manuel, J. T. Carrondoae, Paula M. Alves. Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia. Vaccine. – Volume 32. – Issue 24, 19 May 2014. – P. 2878–2881.

16. Assessment of the antibody response to Peste des petits ruminants (PPR) disease vaccination in a flock of Sirohi goat kids. G. R. Gowane Najif Akram S. S. Misra Ved Prakash Arun Kumar. Small Ruminant Research. – Volume 138, May 2016. – P. 20–24.

17. Balogun F. A. et al. Field evaluation and confirmation of acute peste des petits ruminant outbreak in a flock of West African dwarf goats in Ibadan, Nigeria. Int J of Vet Sci. Med. – 2017. [Электронный ресурс]. – Режим доступа: https://doi.org/10.1016/j.ijvsm.2017.08.004.

18. Banyard A. C., Parida S., Batten C., Oura C., Kwiatek O., Libeau G. Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control. J Gen Virol. – 2010; 91: 2885–97.

19. Bao J., Wang Q., Li L., Liu C., Zhang Z., Li J., Wang S., Wu X., Wang Z. Evolutionary dynamics of recent peste des petits ruminants virus epidemic in China during 2013–2014. VirologyVolume 510, October 2017. P. 156–164.

 

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