Абакин Сергей Стефанович, канд. ветеринар. наук, доцент, вед. науч. сотрудник лаборатории ветеринарной медицины, ФГБНУ «Северо-Кавказский федеральный научный аграрный центр»: Россия, 356241, Ставропольский край, г. Михайловск, ул. Никонова, 49.

Оробец Владимир Александрович, д-р ветеринар. наук, профессор, зав. кафедрой терапии и фармакологии, ФГБОУ ВО «Ставропольский государственный аграрный университет»: Россия, 355017, г. Ставрополь, Зоотехнический пер., 12.

Заерко Виктор Иванович, д-р ветеринар. наук, профессор, профессор кафедры эпизоотологии и микробиологии, ФГБОУ ВО «Ставропольский государственный аграрный университет»: Россия, 355017, г. Ставрополь, Зоотехнический пер., 12.

Климанович Инна Викторовна, канд. мед. наук, доцент кафедры биологии, ФГБОУ ВО «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации: Россия, 355017, г. Ставрополь, ул. Мира, 310.

Тел.: (865-2) 35-22-82

E-mail: orobets@yandex.ru

Список литературы:

1. Virus taxonomy: classification and nomenclature of viruses. Seventh report of the International Committee on Taxonomy of Viruses/ Regenmortel M. H. V. van, Fauquet C. M., Bishop D. H. L., Carstens E. B., Estes M. K., Lemon S. M., Maniloff J., Mayo M. A., McGeoch D. J., Pringle C. R., Wickner R. B. 2000. – 1162. ISBN – 0123702003.

2. Архипов Н. И. Медленные инфекции животных / Н. И. Архипов, И. А. Бакулов, Л. И. Соковых. – М. : Агропромиздат. – 1987. – 191 с.

3. Бурдинский В. Г. Медленные инфекции мелких жвачных / В. Г. Бурдинский // Болезни диких животных: Материалы Междунар. науч,-практ. конф., 28–30 сентября 2004. – Покров, 2004. – С. 248–251.

4. Сидельников Г. Д., Валихов А. Ф. О роли эндогенных ретровирусов в биологии опухолевого роста // Вопросы онкологии. – 2016. – № 6. – Т. 62. – С. 756–766.

5. Genetic determinants of bovine leukemia virus pathogenesis / Willems L., Burny A., Collete D., Twizere J. C., Kettmann R. AIDS // Research and Human Retroviruses. – 2000. – № 16 (16). – С. 1787–1795. DOI: 10.1089/08892220050193326.

6. Bovine Leukemia virus infection in neonatal calves. risk factors and control measures / Ruiz V., Porta N. G., Lomónaco M., Trono K., Alvarez I. // Frontiers in Veterinary Science. 2018. – № 5. – С. 267. DOI: 10.3389/fvets.2018.00267.

7. Бурба Л. Г. Лейкоз и злокачественные опухоли уживотных/ Л.Г.Бурба, А. Ф. Валихов, М. И. Гулюкин и др. / М., ВО «Агропромиздат». – 1988. – С. 244–253.

8. Epidemiological features of BLV natural infection / Lomónaco, M. Alvarez, I. Martínez, C. Porta, N.Merlini, R.Carignano, H.Gutiérrez, G. Trono, K. M. Mammerickx, D. Portetelle, K. de Clercq, A. Burny // Retrovirology. – V. 11, I. 1. – P. 45.

9. Experimental transmission of enzootic bovine leukosis to cattle, sheep and goats: infectious doses of blood and incubation period of the disease / M. Mammerickx, D. Portetelle, K. de Clercq, A. Burny // Leuk Res, 11 (1987). – Р. 353–358. [Электронный ресурс]. – Режим доступа: doi.org/10.1016/01452126(87)90180-9.

10. Experimental infection of sheep with Bovine leukemia virus (BLV): Minimum dose of BLV-FLK cells and cell-free BLV and neutralization activity of natural antibodies [Infección experimental en ovinos con el virus de leucosis bovina: dosis mínima de células BLV-FLK y virus libre de células, y actividad neutralizante de anticuerpos naturales] / Porta N. G., Alvarez I., Suarez Archilla G., Abdala A., Trono K. // Revista Argentina de Microbiologia // Revista Argentina de Microbiología. – 2019. In Press, Available online 22 April 2019.

11. Characterization of minimal lesions related to the presence of visna/maedi virus in the mammary gland and milk of dairy sheep / Gayo E., Polledo L., Magalde A., Rossi G., García Marín J. F. // BMC Veterinary Research. – 2019. –No. 15 (1). – P. 109. DOI: 10.1186/s12917-019-1855-3.

12. Kiessling A. A. Retroviruses and reproduction revisited // Journal of Assisted Reproduction and Genetics. – 2018. – No. 35 (11). – P. 1969–1972. DOI: 10.1007/s10815-018-1253-y.

13. CROI 2018: Epidemic trends and advances in HIV prevention / Buchbinder S. P., Liu A. Y. / Topics in Antiviral Medicine. – 2018. – No. 26(1). – P. 1–16. PubMed: 29727292.

14. Methods for diagnosis of prion diseases/ Grigoriev V.B., Podkidyshev A. N., Kalkov S. L., Klimenko S. M. / Voprosy virusologii. – 2009. – No. 5. – P. 4–9.

15. Pulmonary lentivirus infection in sheep / Luján L., Pérez M., de Andrés D., Reina R. // Small Ruminant Research. – 2019. 412. DOI: 10.1016/j.smallrumres.2019.05.006.

16. Pulmonary adenomatosis in a Nellore Jodipi ram / Chandra B. S., Saritha G., Syaama Sundar N., Varshitha K., Sindhu B. S. // Exploratory Animal and Medical Research. – 2018. – No. 8 (2). – P. 211–213.

17. Diagnosis and prevalence of ovine pulmonary adenocarcinoma in lung tissues of naturally infected farm sheep / Sonawane G. G., Tripathi B. N., Kumar R., Kumar J. // Veterinary World. – 2016. – No. 9(4). – P. 365–370. DOI: 10.14202/ vetworld.2016.365-370.

DISTRIBUTION, DIAGNOSIS AND PATHOGENESIS OF RETROVIRAL INFECTIONS IN THE NORTH CAUCASUS REGION

Abakin Sergey Stefanovich, Cand. of Vet. Sci., Ass. Prof., Leading Researcher, North-Caucasian Federal Scientific Agrarian Centre, Mikhaylovsk, Stavropol region, Russia.

Orobets Vladimir Aleksandrovich, Dr. of Vet. Sci., Prof., Head of Depart., Stavropol State Agrarian University, Stavropol, Russia.

Zaerko Viktor Ivanovich, Dr. of Vet. Sci., Prof., Stavropol State Agrarian University, Stavropol, Russia.

Klimanovich Inna Viktorovna, Cand. of Med. Sci., Ass. Prof., Stavropol State Medical University, Stavropol, Russia.

Keywords: epizootology, retroviral infections, leukemia, adenomatosis, maedi-visna disease, sheep, distribution.

Abstract. In the second half of the twentieth century, the role of RNA-containing oncogenic viruses (retroviruses) in the pathology of humans and animals was convincingly proved. It has been shown that the leukemias of many species of domestic animals, birds, and cattle are caused by retroviruses. An extensive program of research aimed atstudying the etiology of human tumor diseases led to the discovery of retroviruses’role in these pathologies. It seems interesting that the causative agent of human leukemia – the T-cell leukemia virus in adults (VTLH) – is close to the causative agent of bovine leukemia (VBL). In the early 80s an epidemic of a new viral disease, acquired immunodeficiency syndrome (AIDS), hit the mankind. The  causative agent of this disease is a retrovirus, it belongs to the genus of lentiviruses. Previously, lentiviruses had already been an object of veterinary virology study: two serious chronic diseases of the sheep, maedi and visna, were associated with them. The detection of lentiviral pathogen AIDS (HIV) has attracted enormous attention to this type of retrovirus. Earlier retroviruses were of interest for medicine and veterinary science as causative agents of tumours diseases; but after the discovery of HIV they began to interest veterinarians and physicians as causative agents of serious infectious diseases. The possibility of hitting sheep with retroviral infections wasstudied on breeding rams. From 24 to 300 sheep aged over 1 year were investigated by serological method in the surveyed farms. The total number of animals examined at 16 farmsin the region was 6411. During the study of blood serum forthe immunodiffusion reaction, 44 samples gave a positive response to the glycoprotein antigen VLKRS, which made 0.7% of the studied number of animals. Simultaneously with the study of leukemia infection prevalence of among the breeding rams, the research work and testing forthe lungs adenomatosis and visn-maedi was conducted. In each farm, 50 to 200 rams over the age of 1 year were examined by a serological method. A total of 4250 animals from 1 to 4 years age were examined in 15 farms of the Stavropol region. During serological examination of blood serum for the immunodiffusion reaction to the lungs adenomatosis, 13 animals gave a positive response. 3200 sheep were tested on the maedi-visna; and 19 animalsreacted positively to this infection.

REFERENCES

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